The UK-based Indian-origin boy Krtin Nithiyanandam, 16, claims finding out the treatment for the most deadly form of breast cancer which is unresponsive to drugs. He claims to found a way to turn triple negative breast cancer that does not respond to drugs, into a type which responds to drugs.
Krtin said he has been trying to work out a way to change difficult-to-treat cancers into something that responds well to treatment. "I've been basically trying to work out a way to change difficult-to-treat cancers into something that responds well to treatment. Most cancers have receptors on their surface which bind to drugs like Tamoxifen but triple negative don't have receptors so the drugs don't work," Krtin was quoted. "The prognosis for women with undifferentiated cancer isn't very good so the goal is to turn the cancer back to a state where it can be treated. The ID4 protein actually stops undifferentiated stem cell cancers from differentiating so you have to block ID4 to allow the cancer to differentiate….I have found a way to silence the genes that produce ID4 which turns cancer back into a less dangerous state", Krtin added.
Importantly, the Triple negative breast cancer does not have receptors and it can only be treated with a combination of surgery, radiation and chemotherapy which lowers the chance of survival.
The teenager was moved to the United Kingdom from India with his parents. He was shortlisted for his therapy idea in the final of the UK-based young scientists programme 'The Big Bang Fair'.